The Women's Health Initiative (WHI) is a longitudinal national health study sponsored by the National Heart, Lung, and Blood Institute (NHLBI) that focuses on strategies for preventing heart disease, breast cancer, colorectal cancer, and osteoporotic fractures in postmenopausal women in the United States. The study includes data from 161,808 women aged 50-79 years old at the time of enrollment. Available...

The Clinical Proteomic Tumor Analysis Consortium (CPTAC) analyzes cancer biospecimens by mass spectrometry, characterizing and quantifying their constituent proteins, or proteome. Proteomic analysis for each CPTAC study is carried out independently by Proteomic Characterization Centers (PCCs) using a variety of protein fractionation techniques, instrumentation, and workflows. Mass spectrometry and...

Data from the ongoing NYU Women's Health Study include biospecimens and survey data with variables concerning health conditions, reproductive history, and dietary habits. Between 1985 and 1991, the NYU Women's Health Study enrolled 14,274 women between the ages of 35 and 65 years old at the Guttman Breast Diagnostic Institute in New York City for a study of endogenous hormones, diet, and risk of breast...

The City Health Dashboard presents city- and/or census tract-level data for over 900 cities across the United States to describe population health within local contexts. Metrics included in the dashboard encompass five broad domains: health outcomes, social and economic factors, health behavior, physical environment, and clinical care. The underlying data originates from a combination of publicly-available...

The dataset contains data collected from twelve Balb/c mice with metastatic breast cancer (4T1 mammary tumors). Six mice were in the control group and six mice were treated with 5-Fluorouracil (5FU) for metronomic chemotherapy for two weeks. Diffusion MRI (dMRI) and Dynamic Contrast-enhanced MRI (DCE-MRI) images were collected at baseline and post-treatment. Immunohistochemically (IHC) stains and measurements...

Data was abstracted from NYU Langone Health electronic health records, the Perlmutter Cancer Center Data Hub, and the NYU Langone Health SARS-CoV-2 Data Mart for all patients treated for breast cancer at Perlmutter Cancer Center either through telemedicine or in-person between February 1, 2020 and May 1, 2020 to determine the incidence of SARS-CoV-2 infection associated with treatment with cytotoxic...

Investigators manipulated images from the NYU Breast Cancer Screening Dataset to identify differences in the the features of perception used in diagnosis by radiologists versus deep neural networks (DNNs). Two studies were conducted. In the reader study, a set of 720 exams were processed with Gaussian low-pass filtering at varying severity levels and ten radiologists and five DNNs (trained on unperturbed...

This study showed that basal-like breast cancer (BLBC) is sensitive to suppression of iron-sulfur cluster (ISC) biosynthesis and identified DNA polymerase epsilon (POLE) as an ISC-containing protein that underlies this phenotype. This dataset includes primary RNA sequencing data and other primary data, as well as supplementary data tied to the publication. The supplementary data contains tables, which...

This study performed loss-of-function screens in a transformed breast cell line using a metabolism-restricted short hairpin RNA (shRNA) library to understand differences in metabolic pathway requirements between in vitro model systems and in vivo tumors. They found that cancer cells depend on high levels of the iron–sulfur cluster biosynthetic enzyme NFS1. This dataset includes supplementary data tied...

The Congressional District Health Dashboard (CDHD) was launched in 2023 to present actionable and nonpartisan data on health, drivers of health, and health equity for all 435 congressional districts across the United States and Washington DC. Like the City Health Dashboard, available metrics include health outcomes, social and economic factors, health behavior, physical environment, and clinical care...